Striker Nish is suspended for three of Hibs' next five matches for kicking out at Saints defender Michael Duberry at McDiarmid Park.
Midfielder Kevin McBride is still missing with a hamstring injury, while manager John Hughes - who will be on the touchline prior to starting a six-game ban of his own on March 6 - may wield the axe following the club's heaviest defeat since he took charge.
Hibs (from): Smith, McCormack, Bamba, Murray, Hogg, Hanlon, Miller, Cregg, Zemmama, Rankin, Stokes, Riordan, Stevenson, Gow, Galbraith, Wotherspoon, Benjelloun, Stack, Thicot.
