Ferrie Bodde has been ruled out for the rest of the season after suffering a recurrence of the cruciate knee ligament injury that had already sidelined him for the last five months.
Bodde hobbled off just 29 minutes into his comeback game against Peterborough on Saturday and will require surgery again.
There is some good news for the Swans with Darren Pratley, who was also forced off injured at the weekend with a knee injury, back fit and available for selection.
Cedric van der Gun missed the victory over Peterborough despite recovering from a hamstring problem but is again available after coming through training this week, while Craig Beattie will be hoping to retain his place in the squad after coming off the bench to feature against Posh following his recovery from a foot problem.
But captain Garry Monk (calf), Joe Allen (knee), Andrea Orlandi (hamstring), Jordi Lopez (ankle), Albert Serran (hamstring), Fede Bessone (calf) all remain sidelined and are unlikely to return in the near future, while Gorka Pintado serves the second instalment of his four-match suspension.