Ledley King (thigh), Tom Huddlestone (ankle), Jermaine Jenas (groin), Aaron Lennon (groin) and David Bentley (groin) are out of the match at White Hart Lane.
Jonathan Woodgate (groin) and Carlo Cudicini (wrist and pelvis) are long-term absentees.
Jermain Defoe (hamstring) should be fit to return to the starting line-up after being rested for the 0-0 draw with Fulham in the FA Cup.
Kick-off is at 12.45pm.
Tottenham (from): Gomes, Alnwick, Corluka, Assou-Ekotto, Dawson, Bassong, Bale, Kranjcar, Modric, Palacios, Crouch, Gudjohnsen, Pavlyuchenko, Defoe, Rose, Livermore, Dervite, Parrett, Fredericks, Townsend, Kane, Kaboul, Walker.