Rooney had a knee injury earlier this month and looked to be limping heavily as he left Old Trafford following Sunday's win over Liverpool.
But Ferguson said: "He's okay, there's no problem. He had some bad bruising for a couple of weeks but he's played [since then] and there's no problems with the knee."
Ferguson may start with Ryan Giggs, who came on as a substitute against Liverpool after five weeks out with a broken arm. John O'Shea is back in training and should be available from the beginning of April.
United (from): Van der Sar, Kuszczak, Neville, Rafael, Ferdinand, Vidic, Evans, Evra, Fabio Park, Valencia, Carrick, Scholes, Fletcher, Gibson, Obertan, Giggs, Nani, Rooney, Berbatov, Diouf.