Left-back Chris Barker started Tuesday night's 2-0 victory at Ipswich, but hobbled out of the game after 67 minutes with a hamstring injury that makes him an injury doubt to face Roy Keane's side.
Chris Clark dropped back from midfield to cover for Barker, with on-loan Blackburn midfielder Alan Judge introduced on the wing.
With on-loan Burnley full-back Richard Eckersley (ankle) and David McNamee (hamstring) ruled out and Gary Sawyer having joined Bristol City on loan, Clark may have to fill in at left-back once again.
On-loan West Ham central defender Bondz N'Gala made his Argyle debut at Ipswich and is set for his home bow against a Blackpool side managed by former Argyle boss Ian Holloway.
Centre-half Kari Arnason (hip) and winger Craig Noone (knee) are still sidelined, while striker Ashley Barnes has joined Brighton on loan for the rest of the season.