Keane saw his Town side return to winning ways with a 2-1 home win over Reading on Saturday and is likely to select from the same squad at Pride Park.
However with two games in 48 hours Keane may choose to freshen up his starting XI, so the likes of Shane O'Connor, Owen Garvan, Liam Rosenior, Carlos Edwards, Pablo Counago and Connor Wickham all come into the reckoning.
Goalkeeper Richard Wright could also be among the replacements.
Wright has been out of action since injuring his knee in November but stepped up his comeback with an appearance for the reserves last week.
Keane remains without winger Luciano Civelli, who is out until September as he battles to save his career following a serious knee injury.