The 23-year-old goalkeeper has been a regular in the Rangers line-up since arriving on loan from Wolves, but will return to his parent club on April 6.
Serbian defender Dusko Tosic, a deadline-day loan signing from Portsmouth, is unlikely to be handed his debut as manager Neil Warnock can only name a maximum of five loanees in his matchday squad.
Matt Hill, Tamas Priskin, Jay Simpson and Adel Taarabt seem certain to be involved at the Walkers Stadium, so Tosic may have to wait until after Ikeme has gone back to Molineux.
Antonio German, Lee Cook and Rowan Vine all came on as late substitutes in Saturday's 1-1 draw with Sheffield Wednesday and will hope to feature from the start this time around.
Defender Matt Connolly is set to miss out once again with an ankle problem, while midfielders Gavin Mahon and Martin Rowlands remain sidelined with long-term knee injuries.