The U's suffered a disappointing 2-0 defeat at Exeter on Good Friday, but only goal difference is keeping them out of the top six in League One.
Tierney travelled with the squad to Devon following his recovery from a groin operation but failed to make the bench, although he has a much better chance of featuring against the Lions.
Ashley Vincent missed some training sessions last week due to illness but should retain his place in the squad after playing the final 10 minutes at St James' Park.
But striker Kayode Odejayi again misses out as he continues to battle back from a foot problem.
The match kicks off at 1pm.