The Argentina international came off in last week's 2-0 defeat to Chelsea and is a major doubt, as is right-back Glen Johnson who missed that game with a calf injury.
Central defender Jamie Carragher is hopeful of recovering from a twisted ankle to face the Tigers to play in his 435th league match, surpassing the record of former captain Alan Hansen, and his 629th Liverpool game overall.
Liverpool (from): Reina, Mascherano, Carragher, Kyrgiakos, Agger, Lucas, Gerrard, Benayoun, Aquilani, Babel, Kuyt, Cavalieri, Ngog, Pacheco, Ayala, Degen, El Zhar, Plessis.
