Former Inverness goalkeeper Michael Fraser will make his debut while youngsters Steven Saunders and Jonathan Page are vying for the right-back role, with Paul Quinn absent as he bids to secure a move to Cardiff.
Motherwell have also lost Graeme Smith, Artur Krysiak, Brian McLean, Maros Klimpl, Stephen Hughes, Bob Malcolm, David Clarkson and Cillian Sheridan from the squad that finished last season.
Kick-off at Airdrie's Excelsior Stadium is at 8.05pm.
Motherwell (from): Fraser, Page, Hammell, Reynolds, Craigan, O'Brien, Lasley, McGarry, Smith, Sutton, Murphy, Archdeacon, McHugh, Saunders, Hutchinson, Slane, McPake, Meldrum.
