Fernando Guerrero, Chris McCann, Kevin McDonald, Martin Paterson and Jay Rodriguez will all miss Sunday's Premier League encounter at Ewood Park.
Guerrero injured his hamstring and McDonald sustained a knee problem in a reserve game 10 days ago.
And Rodriguez became the third of Owen Coyle's players to be ruled out until Christmas when he fractured his ankle in the same match, joining Paterson and McCann, who both have knee injuries, on the sidelines.
Kick-off at Ewood Park is 1pm.
Clarets (from): Jensen, Caldwell, Mears, Eckersley, Duff, Carlisle, Bikey, Jordan, Alexander, Fletcher, Elliott, Blake, Thompson, Eagles, Penny, Kalvanes, Gudjonsson, Edgar, Easton, Nugent.