Striker Wright picked up a calf knock during the club's recent trip to Austria, while goalkeeper Bossu has been struggling with a hamstring strain.
That means new signing Stuart Nelson goes straight into the squad for what is Mark McGhee's first competitive game in charge but he will play second fiddle to number one Jamie Langfield against the Czech Republic outfit at Pittodrie on Thursday night.
Aberdeen (from): Langfield, Vidal, Diamond, Mulgrew, Considine, Pawlett, Duff, McDonald, Foster, Kerr, Aluko, Young, Miller, Mackie, Maguire, Nelson, Paton, Stewart, Clark, Ross, Crawford, Bateman.
