The Cottagers, already without Andy Johnson, will also be missing Danny Murphy, Bobby Zamora and Paul Konchesky as they seek to defend a 3-1 first-leg lead.
Striker Johnson suffered a broken collarbone in that encounter last Thursday at Craven Cottage, while captain Murphy, striker Zamora and left-back Konchesky all picked up knocks in the 2-0 defeat to Chelsea on Sunday.
Hodgson has yet to decide who he will bring into his side for the match at the Zvezda Stadium - which has an artificial pitch - but knows there is still work for Fulham to do.
