Only goalkeeper David Stockdale and defender John Pantsil survive from the starting line-up that defeated Everton 2-1 in the Premier League on Sunday.
First-team regulars Danny Murphy, Clint Dempsey, Paul Konchesky, Damien Duff and Mark Schwarzer are in the treatment room but are expected to return for Sunday's clash with Wolves.
Hodgson has opted to rest the likes of Andrew Johnson, Bobby Zamora and Brede Hangeland and will call on first-team fringe players such as Erik Nevland and Bjorn Helge Riise.
Fulham (from): Zuberbuhler, Stockdale, Stoor, Pantsil, Kelly, Baird, Smalling, Andranik, Riise, Davies, Greening, Nevland, Kamara, Seol, E Johnson, Elm, Dikgacoi.
