Sixteen-year-olds Jack Bidwell and Luke Garbutt are in contention to feature, with qualification to the last 32 already assured and the squad riddled with injuries.
Moyes will rest his key players, with goalkeeper Carlo Nash coming into the team, while Tony Hibbert will captain the side as he makes a club record 20th European appearance.
The match kicks off at 8.05pm.
Everton (from): Nash, Coleman, Duffy, Hibbert, Bidwell, Osman, Forshaw, Baxter, Rodwell, Yakubu, Agard, Cahill, Howard, Baines, Bilyaletdinov, Pienaar, Fellaini, Jo, Saha, Yakubu, Akpan, Mustafi, McCarten, Garbutt.
