Pearson introduced forward Paul Gallagher at half-time of last week's 2-0 defeat of Crystal Palace and after the former Blackburn man scored both goals he is expected to start at the Madejski Stadium.
Pearson also handed on-loan Manchester City full-back Ryan McGivern his first start last Tuesday and he will again start ahead of Bruno Berner.
The Royals have not won at home since January and if Leicester can pick up three points they will move back into the play-off places.
Bulgarian defender Aleksandar Tunchev remains the only absentee as he recovers from another knee operation as Pearson looks to extend the Foxes' unbeaten run to five.
