Robert Snodgrass was scheduled to join up with George Burley's Scotland squad ahead of their friendly in Japan, but has pulled out due to a knee injury.
Striker Luciano Becchio will also be missing from Leeds' squad as he sustained an ankle injury in Saturday's goalless draw with Charlton.
Grayson could call on Mike Grella to start up front and Andy Robinson and Enoch Showunmi will be hoping to start, while latest signing Davide Somma could be included in the squad.
Defender Leigh Bromby remains doubtful with an infected foot, goalkeeper Shane Higgs has a thigh strain and Jason Crowe is still struggling with a hamstring injury.
