Rodwell became the latest addition to manager David Moyes' lengthy list of absentees when he suffered a hamstring injury in Thursday night's Europa League defeat by BATE Borisov.
The club are awaiting the results of a scan to determine how many games the 18-year-old will miss.
Forward Jo is struggling after turning his ankle and suffering from flu, but Tim Cahill is back after being suspended for last week's trip to Chelsea.
Leon Osman could come into the reckoning at Goodison Park after playing 81 minutes against Borisov.
Everton (from): Howard, Heitinga, Baines, Hibbert, Cahill, Gosling, Bilyaletdinov, Fellaini, Pienaar, Saha, Yakubu, Neill, Nash, Jo, Baxter, Agard, Wallace, Duffy, Osman, Mustafi, Akpan, Coleman.