Reading and Charlton have refused the goalkeeper and striker permission to play, so Rhys Evans and Darryl Duffy will hope to be involved.
Manager Paul Trollope was expected to make changes for the clash anyway, with the Pirates on a five-game losing streak - a run that dates back to their 3-2 win over Saints at the end of September.
Defender Danny Coles could make a surprise return after resuming training following a knee injury, while Chris Lines (shin) is also pushing for a start.
Aaron Lescott will miss out with a groin injury, though, and will be missing for a number of weeks.
The match kicks off at 7.45pm.