The Togo frontman scored and also picked up a three-match ban for an ugly clash with Robin van Persie when the two sides met earlier this season, since when Adebayor has struggled for form.
Kolo Toure is also in line to face his former club at Eastlands as City look to end a run of seven successive quarter-final defeats since they last reached the semi-finals of a major competition, the 1981 FA Cup.
Gareth Barry has been experiencing slight discomfort from separate injuries to groin and knee but Mark Hughes is confident the England star will be fit.
City (from): Given, Taylor, Richards, Zabaleta, Toure, Lescott, Onuoha, Bridge, Garrido, Wright-Phillips, De Jong, Kompany, Johnson, Ireland, Barry, Robinho, Bellamy, Adebayor, Tevez, Santa Cruz, Benjani.
