Owen, who was already wearing a face mask, was forced off just before half-time in Tuesday's 2-2 draw against Torquay having sustained another blow to his fractured cheekbone. He has now undergone minor surgery and will be sidelined for up to two weeks to ensure the injury fully heals.
Adams hauled off Louis Dodds after just 35 minutes of the midweek draw such was his displeasure at the former Lincoln man's performance, with new signing Sean Rigg taking his place and contributing with an impressive display.
His performance leaves Adams with at least one selection dilemma as he looks to guide Vale into the hat for a potentially lucrative third-round tie.
Captain Tommy Fraser serves the second game of a three-match suspension while striker Danny Glover has completed a loan switch to Rochdale and will therefore not be available.
Midfielder Doug Loft (groin) and loan forward Lewis Haldane (knee) are both doubts but striker Geoff Horsfield played 65 minutes for the reserves on Wednesday night having missed out of late due to a groin injury and he could find himself on the bench.