Kisnorbo has missed the last three matches with a knee injury and Grayson has given nothing away as to the Australia international's recovery.
With skipper Richard Naylor sidelined due to a calf problem, Lubo Michalik has partnered Leigh Bromby in the last three matches and will continue if Kisnorbo misses out again.
Max Gradel, on loan from Leicester, is ineligible, while Grayson is expected to recall Luciano Becchio up front alongside Jermaine Beckford as on-loan Wolves forward Sam Vokes does not have permission to play.
Hogan Ephraim, on loan from QPR, is another who is unavailable for Leeds, who hope to renew their rivalry with old foe Manchester United in the third round.
