Left-back Ashley Cole is sidelined with a broken ankle, while midfielder Deco and right-back Juliano Belletti are out with knee injuries.
Ancelotti has named his side for the cup clash and Hilario and Daniel Sturridge will get a run-out against Dave Jones' Bluebirds at Stamford Bridge.
Ancelotti told the club's website: "Tomorrow we play Hilario in goal, defenders are Ferreira, Alex, Carvalho and Zhirkov. Midfielders Lampard, Mikel, Ballack, and strikers Sturridge, Joe Cole and Drogba.
"You want the bench? Turnbull, Bruma, Ivanovic, Malouda, Matic, Borini and Kalou.
"We have some problems with Deco because he has a little problem, and Belletti, they will be ready for next week. Bosingwa is working and again, maybe he needs three weeks."
Kick-off is at 12pm.
Chelsea (from): Hilario, Ferreira, Alex, Carvalho, Zhirkov, Lampard, Mikel, Ballack, Sturridge, J Cole, Drogba. Subs: Turnbull, Bruma, Ivanovic, Malouda, Matic, Borini, Kalou.