One enforced switch will be that of on-loan forward Frank Nouble, who is ineligible for the tie having played earlier in the competition for West Ham.
Nouble put in a promising debut display on Tuesday as victory over Scunthorpe took Albion to the top of the Championship table.
It remains to be seen how many changes Di Matteo will make from that game, but striker Ishmael Miller (ankle), defender Marek Cech (hamstring), winger Jerome Thomas (suspended) and midfielders James Morrison (heel) and Giles Barnes (Achilles) all remain unavailable.
Di Matteo has also confirmed some youth-team players will be on the bench for the encounter, with the Baggies boss possibly having one eye on Tuesday's crunch Championship clash at Cardiff.
