The Portuguese hardman was sent off in Pompey's midweek 1-1 draw with Sunderland.
Avram Grant may also be unable to call upon Serbian defender Dusko Tosic, who is set to sign for the club but is yet to receive international clearance.
Michael Brown (back), Kevin-Prince Boateng (ankle), Anthony Vanden Borre (leg), Hermann Hreidarsson (Achilles) and John Utaka (hamstring) are also doubts.
Kick-off at St Mary's is at 12.30pm.
Pompey (from): James, Mokoena, Mullins, Vanden Borre, Piquionne, Ben-Haim, Wilson, Finnan, Utaka, Webber, Hughes, Ashdown, Belhadj, Yebda, Dindane, Owusu-Abeyie, O'Hara.
