Lille take a 1-0 lead into the game against Liverpool courtesy of Eden Hazard's late free-kick in France last week.
And Garcia is confident his players will cope with a big European night on Merseyside, as they did in the previous round when they travelled to Fenerbahce for the second leg.
Then, leading 2-1, they drew 1-1 in Istanbul thanks to Adil Rami's 85th-minute goal.
"There is no need to motivate the players for a game like this. The motivation has to be to get as far as we possibly can," said Garcia.
"It will be the same kind of mindset. We will need to score, not only defend and play for 0-0.
"We have more chance to qualify if we score.
"The main thing is, no matter what the atmosphere is like, it is about the 11 players out there.
"We know we are playing against a legendary side in a very atmospheric - almost mythical - stadium of legends but we have experienced this against Fenerbahce away from home.
"It doesn't really matter what Liverpool think it is what is in our mind that counts.
"The major goal is to keep a clean sheet initially.
"It is paramount not to concede but the only good news is for us to qualify for the quarter-finals."
Garcia said his players had been boosted by their first-leg victory, when they dominated possession for long periods.
"We will be fighting every inch of the way for our cause and we can take confidence from the first leg where we more than matched Liverpool," he added.
"We just want to match that good performance in the first leg with another."
Lille captain Rio Mavuba said he did not think Liverpool's 4-1 victory over Portsmouth on Monday would have much bearing on this encounter.
"Portsmouth gave them a slightly easier ride than we intend to give them," said the midfielder.
"We will set out to get that all-important away goal and make things even more difficult.
"All that Liverpool are serves to provide us with motivation."
Lille are still without defenders Nicolas Plestan and Mathieu Debuchy, and forwards Tulio de Melo and Gervinho, who all have long-term injuries.