Pavlyuchenko suffered a hamstring injury at Stoke at the weekend and could miss out but Spurs boss Harry Redknapp is hoping Danny Rose (knee) and David Bentley (virus) will be passed fit after training on Tuesday.
Younes Kaboul is cup-tied but Wilson Palacios returns to the midfield after being rested for the league win at Stoke because he is one booking away from a two-match ban.
Defender Jonathan Woodgate (groin) and goalkeeper Carlo Cudicini (wrist/pelvis) are long-term absentees.
Spurs (from): Gomes, Alnwick, Corluka, Bassong, Dawson, Assou-Ekotto, Rose, Bentley, Kranjcar, Modric, Palacios, Bale, Pavlyuchenko, Crouch, Gudjohnsen, Livermore, Dervite, Parrett, Fredericks, Townsend, Kane.
