But the Terriers boss has no new injury or suspension problems after the first leg at the Galpharm Stadium over the weekend ended goalless.
Versatile defender/midfielder Clarke, operating at right-back, sustained a knee injury on Saturday and was replaced during the closing stages by Robbie Williams.
Clark is expected to switch Lee Peltier to right-back at the Den and recall Williams to his starting line-up, while Dean Heffernan provides an alternative option.
Midfielder Danny Drinkwater, on loan from Manchester United, also limped off late on on Saturday, but was suffering from cramp and should start.
Nathan Clarke, Theo Robinson, Robbie Simpson and Nathan Eccleston were all unused substitutes in the first leg and will be anxious to play some part in the Terriers' bid to reach their first play-off final since 2004.