Wolves will be without suspended skipper Karl Henry for the visit of the Hammers.
Midfielder Henry will be starting a three-game ban for his red card in the defeat at Wigan before the international break.
Veteran defender Jody Craddock will wear the captain's armband in his absence.
Henry is likely to be replaced by David Jones who was dropped against the Latics while summer signing Stephen Hunt is in contention for a place on the bench.
Hunt appeared in midweek for the reserves - his first action since being sidelined with a foot injury in February when still a Hull player.
West Ham manager Avram Grant has confirmed Thomas Hitzlsperger will be sidelined for the next four months due to a thigh injury.
Hitzlsperger joins Zavon Hines and Jack Collison (both knee) on the long-term injury list ahead of Saturday's Premier League trip to Molineux to face Wolves.
Kieron Dyer is in contention to return after overcoming a stomach bug that saw him miss the 1-1 home draw with Fulham two weeks ago.
Valon Behrami, Herita Ilunga and Benni McCarthy, who have all had their own fitness concerns of late, are all improving and come into contention.
Wolves (from): Hahnemann, Foley, Craddock, Berra, Ward, Jarvis, Jones, Mancienne, Van Damme, Fletcher, Doyle, Ebanks-Blake, Elokobi, Halford, Bent, Hennessey, Edwards, Milijas, Stearman, Mouyokolo, Mujangi Bia, Hunt.
West Ham (from): Green, Jacobsen, Tomkins, Upson, Ilunga, Parker, Dyer, Noble, Piquionne, Boa Morte, Cole, Obinna, Kovac, Faubert, Behrami, Stech, Barrera, Ben Haim, Gabbidon, Da Costa, McCarthy, Spector, Reid.