Lee McCulloch is one of several players who will miss out for Gers.
The midfielder is sidelined for the next couple of weeks after suffering a groin injury.
Goalkeeper Allan McGregor is suspended after receiving a retrospective ban, while the visit of Craig Brown's men comes too soon for James Beattie and Kirk Broadfoot.
Rangers are also without Nikica Jelavic as he recovers from ankle ligament damage.
Motherwell have a full squad available the game.
Marc Fitzpatrick (knee) and Shaun Hutchinson (hamstring) have been fighting to get back to full fitness.
But they and Esteban Casagolda, who has recovered from knee surgery, may struggle to get back into the on-form team.
Rangers (from): Alexander, Whittaker, Papac, Weir, Bougherra, Davis, Edu, Weiss, Naismith, Miller, Lafferty, Foster, Little, Wylde, Hutton, Webster, McMillan, Adam.
Motherwell (from): Randolph, Saunders, Hammell, Craigan, Reynolds, Hateley, Jennings, Lasley, Humphrey, Murphy, Blackman, Sutton, Gow, Forbes, McHugh, Page, Fitzpatrick, Hollis.