Hull's latest loan signing Vito Mannone will go straight in their squad.
The Arsenal goalkeeper, who will stay with Hull initially until January, is expected to be among the substitutes against the Blades. The 22-year-old arrived at Arsenal from Atalanta in 2005 and has had to be patient at the Emirates Stadium.
Tigers manager Nigel Pearson will be without midfielder Jimmy Bullard again as he works his way back to fitness following a knee injury, but defender Paul McShane is expected to be available.
McShane was feared to have damaged ankle ligaments when forced out of Saturday's 1-1 draw at Leicester, but x-ray results have given him the all-clear.
Summer signing James Harper, still to appear for Hull after breaking a bone in his foot during the summer, is edging closer, but not yet ready for first-team action.
Sheffield United striker Jamie Ward returns to contention following suspension.
The Blades forward was shown a straight red card in last month's defeat at Leeds, but provides Gary Speed with extra options up front.
Richard Cresswell partnered Daniel Bogdanovic up front at the weekend, with Ched Evans replacing the latter midway through the first half, and Speed must decide whether or not to split them up.
Midfielder Nick Montgomery will miss out should he require an injection in his Achilles, but will otherwise be available and on-loan Manchester United defender Ritchie De Laet is expected to be fit after being forced off late on against Burnley on Saturday due to a calf strain.
The Blades, chasing their first win in five league games, have won only once on the road this season, at Derby in early September.