Millwall manager Kenny Jackett is boosted by having Alan Dunne and Liam Trotter back in the ranks.
The former is returning from a one-match ban having picking up five yellow cards this term, while the latter has missed the last three games through suspension after being sent off against Cardiff.
Both should make an immediate return to the starting line-up with Scott Barron, who impressed as a makeshift right-back in Saturday's 1-0 win over Crystal Palace, and Tamika Mkandawire likely to make way.
Theo Robinson went off with cramp after netting the winner against the Eagles, but is fit and should retain his place in the XI, while Shaun Batt (knee) remains a long-term absentee.
Pompey manager Steve Cotterill will be without midfielder Aaron Mokoena.
The 29-year-old picked up his fifth yellow card of the season during Saturday's dramatic 3-2 victory over Watford and, subsequently, has been handed a one-match ban.
John Utaka missed the match against the Hornets through a slight hamstring problem and is rated as 50-50 for the clash with the Lions.
Hermann Hreidarsson, who has yet to feature this season, could return to the fold as he continues his rehabilitation from the Achilles injury he picked up against Tottenham last season.
Striker Danny Webber is another month away from returning, while youngsters Tom Kilbey (knee) and Billy Goddard (shin) are still on the sidelines.