Doncaster's injury troubles have deepened with midfielder Simon Gillett ruled out of the game after sustaining a knee injury in midweek.
Gillett, feared to have suffered medial ligament damage, joins James O'Connor (hamstring), Wayne Thomas (knee) and James Chambers (knee) on the sidelines, while midfielder Martin Woods (groin) and central defender Adam Lockwood (big toe) could face late fitness tests.
Another defender, George Friend, is a long-term absentee after suffering a similar injury to Gillett the previous week and centre-half Shelton Martis has suffered a recurrence of his groin injury.
Defender Joseph Mills, on loan from Southampton, is expected to make his second start for Rovers and striker Billy Sharp will face his former club for the first time competitively since first arriving at the Keepmoat on loan last season.
Stephen Jordan is expected to miss the game.
The Blades defender sustained the injury in the midweek win at Hull and is expected to be replaced by Ritchie De Laet, on loan from Manchester United, in the starting line-up.
The Blades will also be without midfielder Nick Montgomery again as he has had an injection in a bid to resolve an Achilles problem, while striker Ched Evans remains sidelined due to a recurrence of his groin injury.
Striker Jamie Ward is pushing for a return to the starting line-up, but manager Gary Speed is expected to keep faith with Richard Cresswell and Daniel Bogdanovic up front following Tuesday night's success.
The Blades are hoping to climb into the top half of the table with their third league win of the season away from home.