Ryan Bertrand is suspended for the home side.
The on-loan full-back collected his fifth yellow card of the season during the midweek victory over Middlesbrough and must serve a one-match ban.
Boss Billy Davies, who could be back in the dug-out after a viral infection forced him to miss the last two matches, has several options to replace the Chelsea defender.
Joel Lynch is a natural deputy, while midfielder Chris Cohen has regularly been asked to fill in at full-back. Chris Gunter could switch sides but that would leave a void to fill at right-back.
Nathan Tyson (knee) remains out along with fellow forward Robert Earnshaw, who is not yet ready to return despite making good progress in his recovery from a calf problem.
Ipswich goalkeeper Marton Fulop could again miss out.
Fulop missed the 2-1 defeat at Watford in midweek after picking up a back injury in training and the Hungarian is not expected to recover in time.
That will see Brian Murphy keep his place with Arran Lee-Barrett providing cover on the bench.
Left-back Mark Kennedy will be out for at least another fortnight with a hamstring injury while on-loan Celtic defender Darren O'Dea had knee surgery on a problem that has dogged him since September last week and now faces six weeks on the sidelines.
Substitutes Connor Wickham, Ronan Murray and Carlos Edwards all impressed after coming on at Vicarage Road and Keane confirmed that all three - along with Andros Townsend - could come into his starting XI.
Keane started his playing career in England with Forest when he was signed from Cobh Ramblers in 1990.