West Ham captain Matthew Upson looks certain to miss out with a hamstring injury he received against Newcastle last week.
Upson has had intensive treatment this week but manager Avram Grant admitted he was reluctant to risk the defender in the Premier League match.
Striker Frederic Piquionne is also doubtful with a leg injury but Grant reported no other major worries although he admitted his squad were "tired" after their Carling Cup victory against Stoke.
Arsenal will be without left-back Kieran Gibbs after the England defender suffered knee ligament damage in the Carling Cup win at Newcastle.
Goalkeeper Manuel Almunia (elbow), defender Thomas Vermaelen (Achilles) and midfielder Abou Diaby (ankle) are still not yet match fit, while Jack Wilshere serves the last of his three-match ban.
Long-term absentees Aaron Ramsey and Robin van Persie are scheduled to return to full training at the end of next week.
Gunners (from): Fabianski, Clichy, Squillaci, Koscielny, Sagna, Arshavin, Fabregas, Song, Walcott, Nasri, Chamakh, Szczesny, Eboue, Djourou, Rosicky, Bendtner, Denilson, Eastmond.
Hammers (from): Green, Jacobsen, da Costa, Ilunga, Gabbidon, Behrami, Barrera, Parker, Noble, Obinna, Cole, Piquionne, McCarthy, Stech, Ben-Haim, Boa Morte, Faubert.