Wolves boss Mick McCarthy has no fresh injury worries.
Full-back Ronald Zubar and central defender Jody Craddock have still not recovered from ankle and hip problems respectively while midfielder Adlene Guedioura (broken leg) and winger Michael Kightly (knee) remain long-term absentees.
McCarthy may be tempted to persevere with the line-up which impressed during last weekend's 2-1 home success over Manchester City - their first win in seven league games.
Wolves will be making a quickfire return to Old Trafford, having been beaten 3-2 in a Carling Cup tie 10 days ago.
Sir Alex Ferguson will make a late decision about whether to bring Ryan Giggs back for the encounter.
Giggs has featured just once in United's last eight games due to a hamstring problem and Ferguson may decide the bench is the best place for the veteran Welshman, with Wednesday's Manchester derby in mind.
Darren Fletcher (ankle) could feature but Nani (groin) and Darron Gibson (virus) are definitely out, along with longer-term casualties Wayne Rooney (ankle) and Michael Owen (hamstring).
United (from): Van der Sar, Kuszczak, Rafael, Brown, O'Shea, Ferdinand, Vidic, Smalling, Evans, Evra, Fabio, Obertan, Bebe, Carrick, Scholes, Fletcher, Anderson, Giggs, Park, Berbatov, Hernandez, Macheda.
Wolves (from): Hahnemann, Foley, Stearman, Berra, Ward, Jarvis, Henry, Milijas, Edwards, Hunt, Doyle, Hennessey, Fletcher, Ebanks-Blake, Jones, Bent, Mouyokolo, Mujangi Bia, Mancienne, Van Damme.