The Tykes could be without on-loan pair Matt Hill and Chris Wood against the Foxes.
Defender Hill has returned to parent club Wolves for treatment on his injured foot and will definitely miss out so manager Mark Robins could turn to Luke Potter to step into the left-back berth.
Kiwi striker Wood, on loan from West Brom, is struggling with a knee injury but Robins has other options available up front with Paul Hayes, signed on loan in time from Preston to make his debut against Hull last week, expected to continue alongside Andy Gray.
Midfielder Jacob Butterfield is hoping to return to the starting line-up after stepping off the bench against Hull as Barnsley chase their first league win in four games.
Leicester are hopeful Darius Vassell will be cleared to make his debut.
The former England international striker has been training with City since signing for Sven-Goran Eriksson's side on a free transfer last month.
Eriksson had hoped Vassell would feature during last weekend's home win over Preston but there was a problem with international clearance following his release from Turkish club Ankarag|c| at the end of last season.
City should also be boosted by the return from injury of Curtis Davies. The on-loan defender has recovered from the hamstring strain that has ruled him out of the last two matches.
Meanwhile, forward Paul Gallagher has shaken off a knee injury he sustained against Preston.