Freddy Eastwood returns to the fold for the Sky Blues.
The striker has not played since August's 3-1 defeat at Millwall due to a knee injury but is now back in full training and in contention for a place in Aidy Boothroyd's squad.
Full-back Chris Hussey, who has been sidelined with a broken metatarsal, also returns to the frame.
Midfielder David Bell (groin) returns to training on Friday but Saturday's visit of Leeds may come too soon for him while centre-back James McPake is also on the verge of making his comeback.
Gary Deegan earlier this week suffered a setback in his recovery from ankle trouble and will now miss the rest of the season.
Fourth-placed Coventry go into the encounter looking for their third successive victory, with Gary McSheffrey having scored four goals in five games and keen to shoot down the club who opted not to make his loan switch at Elland Road permanent at the end of last season.
Winger Lloyd Sam could return to the Leeds squad.
Sam has missed the last five games due to an unspecified injury but proved his fitness in a behind-closed-doors friendly this week and could give Grayson extra options.
Grayson has no new injury or suspension worries and is not expected to make any unforced changes following his side's 4-1 win at Scunthorpe last Saturday.
Latest loan signing Andy O'Brien is likely to continue alongside Alex Bruce in central defence after making an impressive debut at Scunthorpe.
Grayson could opt for Bradley Johnson in his starting line-up after he replaced Amdy Faye early in the second half last week while Billy Paynter is pushing for his first start after stepping off the bench late on to make his first appearance since arriving from Swindon in the summer.