Preston boss Darren Ferguson will be without Iain Hume for the Barnsley game.
The striker, who netted his third goal for North End in Saturday's 1-1 draw at Bristol City, is on loan from Barnsley and thus ineligible to face his parent club.
Hume's absence could signal a return for youngster Adam Barton but Ferguson will check on the fitness of defender Wayne Brown, who has been suffering with chickenpox.
The centre-back was still able to take his place among the substitutes at the weekend but Craig Morgan may be asked to continue alongside Sean St Ledger again.
Ferguson said: "Obviously he isn't infected now but I'm just trying to put bodies on the bench - we could do with getting more bodies in."
Barnsley will include Garry O'Connor in their squad for the clash after he returned for a second loan spell with the Tykes.
The Birmingham striker made four appearances for Barnsley last month before returning to St Andrew's, but the Scot is back again at Oakwell.
O'Connor could go straight into the starting line-up to partner Andy Gray or Chris Wood as on-loan Paul Hayes does not have permission to play against his parent club.
The Tykes are still without on-loan defender Matt Hill due to a foot injury, so Bobby Hassell and Luke Potter should start again in defence.
Otherwise, Robins has a full-strength squad to choose from as his side, two points clear of the bottom three, chase their first win in five league matches.