Chelsea have fresh injury doubts over defender Alex (knee) and Nicolas Anelka (back) in the run-up to the West London derby.
Midfielder Frank Lampard remains sidelined with a tendon problem but Michael Essien has recovered from the toe injury that kept him out of the Liverpool game on Sunday.
Chelsea striker Didier Drogba will play despite being diagnosed with a bout of malaria.
Fulham defender Carlos Salcido is sidelined for three weeks with ankle ligament damage suffered in the 1-1 draw against Aston Villa at the weekend so misses Wednesday night's clash with leaders Chelsea.
Fulham will also be missing defender Chris Baird who has suffered a thigh tear and is likely to be out for 10 days.
However, he could return for the match against Manchester City.
Chelsea (from): Cech, Ivanovic, Terry, Alex, Cole, Obi, Essien, Ramires, Zhirkov, Drogba, Anelka, Kalou, Malouda, Turnbull, Van Aanholt, McEachran, Borini, Bruma, Ferriera, Sturridge, Kakuta.
Fulham (from): Schwarzer, Kelly, Hangeland, Hughes, Duff, Davies, Greening, A Johnson, Murphy, Gera, Dembele, Dempsey, Stockdale, Pantsil, Etuhu, E Johnson, Briggs.