Ipswich midfielder Grant Leadbitter will serve a one-match ban against the Tykes after picking up his fifth booking of the season during the 2-0 home defeat to Derby in midweek and.
Captain David Norris is also likely to be absent as he continues to struggle with his ankle injury so on-loan Tottenham winger Andros Townsend could start with Jack Colback moving into the middle.
Defender Gareth McAuley is unlikely to feature after he came off against the Rams with an Achilles injury so Jaime Peters could come in.
Defenders Darren O'Dea (knee) and Mark Kennedy (hamstring) were both back on the bench in midweek after lengthy absences and could come into contention.
Midfielder Colin Healy is recovering from a hamstring and then groin injury but would not have been involved anyway.
Garry O'Connor could be handed a starting role for Barnsley as the Tykes chase back-to-back away wins.
O'Connor, in his second loan spell at Oakwell from Birmingham, stepped off the bench to fire Barnsley's winner at Preston in midweek and is expected to partner either Andy Gray or Paul Hayes up front.
Hayes returns to contention after sitting out the game in midweek against his parent club.
Tykes defender Luke Potter has undergone knee surgery to repair cartilage damage and joins fellow left-backs Jay McEveley (knee) and Matt Hill (foot) on the sidelines, so manager Mark Robins, who has no new injury or suspension problems, is expected to stick with Kieran Trippier in that role.
Barnsley, who clinched their first away win at Preston, have lost five times on the road in the Championship this season.