Hamilton will be without Nigel Hasselbaink, who is struggling with a hamstring injury.
Skipper Alex Neil and long-term casualty James Gibson both remain on the sidelines.
Inverness midfielder Russell Duncan will miss out again with a groin injury, while Shane Sutherland is a doubt after being struck by a bout of tonsilitis.
Gil Blumenshtein, David Proctor, Chris Innes (all hamstring) and Kenny Gillet (knee) remain on the sidelines.
Hamilton (from): Cerny, Canning, McLaughlin, Graham, McDonald, Goodwin, Buchanan, Mensing, Routledge, F Paixao, M Paixao, Imrie, Casalinuovo, Murdoch, Elebert, Skelton, Gillespie, Kirkpatrick.
Inverness (from): Esson, Tokely, Munro, McCann, Cox, Shinnie, Duff, Hayes, Ross, Foran, Rooney, Odhiambo, Sutherland, Golabek, McBain, Tuffey, Morrison, Sanchez.