Strikers Colin Nish and Derek Riordan could return for Hibs.
Nish has been absent with an ankle problem but trained on Thursday, while Riordan is available again after missing Wednesday night's 3-0 win at Rangers through suspension following his dismissal in the Edinburgh derby.
Manager Colin Calderwood could, though, opt for an unchanged team after victory at Ibrox, with Darryl Duffy (foot), Graham Stack (back) and Merouane Zemmama (knee) still out.
Motherwell manager Craig Brown has revealed Keith Lasley has a chance of making the clash against Hibs.
Lasley has missed four games with a hamstring injury but is making good progress.
Brown will have a full squad to choose from if the midfielder proves his fitness.
Hibernian (from): Brown, Wotherspoon, Hogg, Bamba, De Graaf, Miller, Rankin, Hanlon, Thicot, Trakys, Stevenson, Galbraith, Dickoh, Grounds, McBride, Murray, Smith, Stephens, Nish, Riordan, Hart, Horner.
Motherwell (from): Randolph, Saunders, Hammell, Craigan, Reynolds, Hateley, Jennings, Humphrey, Sutton, Gow, Blackman, Murphy, Lasley, Forbes, Fitzpatrick, Casagolda, Page, Hollis.