Aston Villa striker Gabriel Agbonlahor is battling to be fit for the fixture.
Agbonlahor has missed training for the past two days through illness and his condition will be assessed during the next 24 hours by manager Gerard Houllier. Fellow striker John Carew is available after a four-game absence due to a calf problem.
Houllier confirmed defender James Collins will play after he missed the 2-0 defeat at Blackburn, also with a calf injury. Young midfielder Jonathan Hogg is Villa's only new injury doubt after suffering an ankle injury at Ewood Park. Robert Pires will be included in the 18 to face his former club.
Cesc Fabregas is out for Arsenal after being ruled out for an estimated two weeks with a hamstring strain.
Fellow midfielder Emmanuel Eboue is out for up to eight weeks with a knee ligament strain, strikers Robin van Persie and Andrey Arshavin come back into the squad after being rested for Tuesday night's Champions League game at Braga, while defender Gael Clichy could shake off a back problem.
Goalkeeper Manuel Almunia (elbow) may return, but centre-half Thomas Vermaelen (Achilles) and midfielder Abou Diaby (ankle) remain out. Aaron Ramsey has joined Nottingham Forest on loan.
Aston Villa (from): Friedel, Luke Young, Clark, Dunne, Warnock, Ireland, Hogg, Bannan, Downing, Ashley Young, Agbonlahor, Carew, Collins, Pires, Delfouneso, Herd, Guzan, Osbourne, Lichaj, Lowry.
Arsenal (from): Fabianski, Almunia, Gibbs, Koscielny, Clichy, Squillaci, Sagna, Nasri, Song, Wilshere, Rosicky, Walcott, Bendtner, Szczesny, Denilson, Djourou, Chamakh, Emmanuel-Thomas, Arshavin, Van Persie.