West Ham will check on the fitness of Scott Parker (virus), Kieron Dyer (hamstring) and Valon Behrami (hip) ahead of the game.
Young forward Zavon Hines (knee) is fit again, but Mark Noble (hip) is set for another spell on the sidelines having only just returned from an appendix operation.
Manuel Da Costa (ankle), Thomas Hitzlsperger (thigh), Jack Collison (knee) and Junior Stanislas (groin) remain out.
Wigan pair Hugo Rodallega and Antolin Alcaraz are suspended for the trip to London following their sendings-off at Manchester United last week. Rodallega is out for three games and Alcaraz one.
Defender Gary Caldwell has an outside chance of returning from a thigh injury while on-loan Tom Cleverley is back after missing the game against parent club United.
Emmerson Boyce (hamstring) and James McCarthy (ankle) remain on the sidelines. Veteran goalkeeper Mike Pollitt will be on the bench following Chris Kirkland's loan move to Leicester.
West Ham (from): Green, Gabbidon, Jacobsen, Upson, Ilunga, Tomkins, Kovac, Boa Morte, Piquionne, Cole, McCarthy, Obinna, Spector, Stech, Reid, Nouble, Parker, Dyer, Behrami, Hines.
Wigan (from): Al Habsi, Stam, Gohouri, Figueroa, Thomas, Diame, N'Zogbia, Gomez, Cleverley, Di Santo, Moses, McArthur, S Caldwell, G Caldwell, Boselli, Di Santo, Watson, McManaman, Pollitt.