Captain Robbie Savage and midfield partner James Bailey are expected to return to the Derby starting line-up against the Royals.
Savage missed the defeat to Bristol City with an ankle injury while Bailey was ill last weekend. Both players have resumed training.
Rams boss Nigel Clough is considering resting Tomasz Cywka after feeling the Polish forward looked tired at Ashton Gate, where he made his eighth consecutive start.
Dean Moxey could also come back into the team at full-back should Clough wish to make further changes.
Striker Shefki Kuqi and goalkeeper Frank Fielding will be missing from the squad after returning to Swansea and Blackburn respectively following the end of their loan spells.
Reading could move up to seventh in the Championship, if they can find the net at Pride Park.
The Royals are on a winless run of six games, having drawn their last five and failed to score in the last two.
Long-term absentee and usual Reading captain Ivar Ingimarsson (hamstring) completed 90 minutes for the reserves in midweek and the defender could feature at Pride Park. His Icelandic compatriot Brynjar Gunnarsson (knee) is also back in training but the defensive midfielder is not expected to start.
Young midfielder Jake Taylor came through an hour of the reserve match following his recovery from knee surgery and will rejoin full training soon.
Irish defender Julian Kelly (hamstring) is another injury concern but was not expected to compete for a first-team berth.