On-loan Leeds defender Andy O'Brien is a major doubt for the clash with the leaders.
Neill Collins stepped in alongside Alex Bruce in central defence for last week's win at Burnley following O'Brien's late withdrawal due to a thigh strain and will retain his place if the Bolton centre-half fails to make it.
Manager Simon Grayson is not expected to make many changes as his side look to stretch their unbeaten run to nine matches and close the gap on Rangers to three points.
Defender Paul Connolly returned to the side last week following suspension and is expected to retain his place, as is midfielder Bradley Johnson, recently placed on the transfer list after failing to agree a new contract.
Strikers Billy Paynter, Ross McCormack and Davide Somma are all expected to start on the bench again, with midfielder Jonny Howson playing in advanced role behind 12-goal Luciano Becchio.
Rob Hulse could return to the QPR starting line-up.
The striker was restricted to a place on the bench for the 3-1 loss to Watford last Friday due to a stomach upset, but if passed fit he will probably replace Heidar Helguson up front.
Boss Neil Warnock is not planning major changes despite that first defeat of the season so the rest of the team could be unchanged.
Patrick Agyemang missed out against the Hornets with a thigh problem and he could be added to the bench along with fellow striker Antonio German, who has been recalled from a loan spell with Southend.
Defender Peter Ramage and midfielders Akos Buzsaky and Lee Cook are still out with knee injuries.