United begin life after Gary Speed with the visit of Swansea.
John Carver has been placed in temporary charge following Speed's appointment as the new Wales manager and he will be able to welcome midfielder Lee Williamson back into the squad.
Williamson has been out since April with a back injury but continued his comeback with 60 minutes in the reserves in midweek and could be in contention for a place on the bench.
Striker Jamie Ward has been laid low with a virus over the last week but he has returned to training and should be involved.
Goalkeeper Richard Wright, who lasted just 53 minutes of his debut before suffering a thigh injury against Barnsley last week, will be given until the last minute to prove his fitness.
Strikers Daniel Bogdanovic and Richard Cresswell are suspended while defender Chris Morgan, who will act as part of Carver's backroom team, will not play again this season with a knee problem.
Swansea have no injury or suspension concerns.
Skipper Garry Monk made his successful comeback from a calf injury in last Friday's 1-1 draw with Millwall, returning to the centre of defence alongside Ashley Williams.
On-loan striker Jermaine Easter also made his Swans debut as a 56th-minute substitute having recovered from a thigh problem, and he will be hoping for more game time.
How manager Brendan Rodgers opts to line up at Bramall Lane remains to be seen but changes are likely after what was a disappointing display against the Lions, with the likes of Darren Pratley, Stephen Dobbie, David Cotterill and Kemy Agustien possible starters.
Another option is the inclusion of striker Shefki Kuqi in City's matchday 18 following his return this week from a three-month loan spell at Championship rivals Derby.
Swansea will be coming up against a familiar face in the form of midfielder Leon Britton, who spent eight popular years with the club before completing a summer switch to the Blades.