William Gallas is set to make a timely return to the Spurs side for the game against the Cottagers.
The defender, who had been skippering the side, has missed the last three and a half weeks with a hamstring strain and should replace Younes Kaboul, who starts a three-match ban.
Jermain Defoe is also suspended, Robbie Keane (hamstring) is doubtful, Carlo Cudicini is out with a shoulder problem, while Tom Huddlestone (ankle), Ledley King (groin), Jamie O'Hara (back) and Jonathan Woodgate (groin) remain sidelined.
Fulham striker Moussa Dembele is likely to miss the game at Spurs as he continues his recovery from an ankle injury.
Dembele has missed the last seven weeks with the knock but Cottagers boss Mark Hughes is confident that the striker will return for the January 4 match against West Brom.
Mark Schwarzer will play his last game before flying out to the Asian Cup with Australia while Fulham will be without long-term absentees Matthew Briggs (calf), Bobby Zamora (leg) and Philippe Senderos (Achilles).
Tottenham (from): Gomes, Pletikosa, Hutton, Corluka, Dawson, Gallas, Bassong, Assou-Ekotto, Sandro, Palacios, Jenas, Bale, Lennon, Bentley, Modric, Dos Santos, Van der Vaart, Crouch, Pavlyuchenko, Keane.
Fulham (from): Schwarzer, Kelly, Salcido, Hughes, Baird, Hangeland, Halliche, Duff, Dempsey, Murphy, Davies, Gera, Etuhu, A Johnson, E Johnson, Stockdale, Pantsil, Kamara, Greening, Dikgacoi.