Valon Behrami could return for West Ham after a month out with a hip injury.
Danny Gabbidon and Tal Ben Haim are back after being rested for Tuesday's draw with Everton, but the game may come too soon for Mark Noble (hip), who is back in training.
Kieron Dyer (thigh), Benni McCarthy (calf), Lars Jacobsen (heel) and Herita Ilunga are also still out.
Thomas Hitzlsperger (thigh), Jack Collison (knee) and Manuel da Costa (ankle) are sidelined until at least February, while Peter Kurucz (knee) is out for the season.
Wolves will again be without a number of key players.
Kevin Doyle (thigh) and Jody Craddock (hip and thigh) will miss the game, but have at least started training.
Karl Henry and Michael Mancienne (both knee) are still out, as is Steven Mouyokolo (back).
Michael Kightly (knee) and Adlene Guedioura (leg) are long-term absentees.
West Ham (from): Green, Ben Haim, Tomkins, Upson, Gabbidon, Barrera, Stanislas, Kovac, Parker, Behrami, Nouble, Spector, Boa Morte, Cole, Obinna, Piquionne, Sears, Reid, Faubert, Boffin.
Wolves (from): Hahnemann, Foley, Jarvis, Jones, Ward, Fletcher, Ebanks-Blake, Stearman, Mujangi Bia, Mouyokolo, Halford, Milijas, Elokobi, Hill, Hennessey, Hunt, Bent, Zubar, Batth.